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Review
. 2016 Nov;18(11):49.
doi: 10.1007/s11940-016-0432-3.

Surgical Treatment of Parkinson's Disease

Leo Verhagen Metman  1 , Gian Pal  2 , Konstantin Slavin  3
Affiliations
Review

Surgical Treatment of Parkinson's Disease

Leo Verhagen Metman et al. Curr Treat Options Neurol. 2016 Nov.

Abstract

Deep brain stimulation is now an established therapy for Parkinson's disease, and DBS continues to be refined. Well-established targets, such as the STN and GPi, have shown clear benefit in reducing motor complications in PD, and other more novel targets, such as PPN are being explored. Furthermore, there have been advances in imaging which allow for improved lead placement and also can reduce patient discomfort. The way electrical current is delivered through the DBS lead is also undergoing a transformation, allowing for more options regarding current shaping, steering, and new stimulation paradigms. The future holds promise for novel methodologies of neuromodulation including closed-loop devices and more focused lesion therapies that alter CNS circuitry.

Keywords: Closed loop; Current steering; DBS; Focused ultrasound; Intraoperative imaging; Stereotactic surgery.

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