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Comment
. 2016 Dec;38(12):1193-1194.
doi: 10.1002/bies.201600204. Epub 2016 Oct 14.

RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)

Andrzej T Slominski  1   2   3 , Michal A Zmijewski  4 , Anton M Jetten  5
Affiliations
Comment

RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)

Andrzej T Slominski et al. Bioessays. 2016 Dec.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. Putative indirect effects of melatonin or its metabolites on RORα activity
1: MT1/MT2-dependent or independent regulation of RORα expression, 2: pentose phosphate pathway generated NADPH, 3: proteasomal degradation, 4. Phosphorylation, M: melatonin, MM: melatonin metabolites, MT1/MT2: G-protein coupled membrane bound melatonin receptors type 1 and 2, QR2: quinone reductase 2, CAL: caldmodulin, TBR: to be defined receptor for M or MM.
See this image and copyright information in PMC

Comment on

References

    1. Cook DN, Kang HS, Jetten AM. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism. Nucl Receptor Res. 2015;2 - PMC - PubMed
    1. Slominski AT, Semak I, Fischer TW, Kim T-K, et al. Metabolism of melatonin in the skin: why is it important? Experimental Dermatology. 2016 - PMC - PubMed
    1. Farez MF, Calandri IL, Correale J, Quintana FJ. Anti-inflammatory effects of melatonin in multiple sclerosis. BioEssays. 2016 - PubMed
    1. Kallen J, Schlaeppi JM, Bitsch F, Delhon I, et al. Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A. J Biol Chem. 2004;279:14033–14038. - PubMed
    1. Slominski AT, Kim TK, Takeda Y, Janjetovic Z, et al. RORalpha and ROR gamma are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB J. 2014;28:2775–2789. - PMC - PubMed

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