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Comment
. 2016 Oct 14:5:e21506.
doi: 10.7554/eLife.21506.

Skin deep

Aitor Casas-Sánchez  1 , Álvaro Acosta-Serrano  1   2
Affiliations
Comment

Skin deep

Aitor Casas-Sánchez et al. Elife. .

Abstract

Trypanosome parasites are hiding in human skin, a discovery that may undermine efforts to eliminate sleeping sickness by 2020.

Keywords: Human African Trypanosomiasis; Trypanosoma brucei gambiense; epidemiology; global health; human; infectious disease; microbiology; mouse; reservoir; skin; transmission; tsetse fly.

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Conflict of interest statement

The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. The transmission of Trypanosoma brucei from the tsetse fly to a human and back again.
When an infected tsetse fly (top) bites a human it injects saliva that contains infectious trypanosomes into the skin. These parasites quickly transform into the “slender” form (blue), which can either go into the bloodstream or remain in the skin and nearby fat (i.e. the subcutaneous adipose). Once the trypanosomes become established in any of these tissues, they can transform into the “stumpy” form (orange) that can re-infect another tsetse fly (grey arrows). Transmission from fat to tsetse is plausible, but has not been demonstrated experimentally and is therefore labelled with a question mark. Parasite reservoirs might be less exposed to the immune system in skin or fat and may play an important role in transmitting sleeping sickness, and in maintaining the trypanosome infection in asymptomatic individuals.
See this image and copyright information in PMC

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