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Review
. 2016 Sep;11(3):343-352.
doi: 10.1016/j.gheart.2016.07.004.

Advances in Understanding Air Pollution and CVD

Joel D Kaufman  1 , Elizabeth W Spalt  2 , Cynthia L Curl  3 , Anjum Hajat  4 , Miranda R Jones  5 , Sun-Young Kim  6 , Sverre Vedal  2 , Adam A Szpiro  7 , Amanda Gassett  2 , Lianne Sheppard  8 , Martha L Daviglus  9 , Sara D Adar  10
Affiliations
Review

Advances in Understanding Air Pollution and CVD

Joel D Kaufman et al. Glob Heart. 2016 Sep.

Abstract

The MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information. Together with extensive phenotyping in MESA-and adding participants and health measurements to the cohort-MESA Air investigated environmental exposures on a wide range of outcomes. Advances by the MESA Air team included not only a new approach to exposure modeling, but also biostatistical advances in addressing exposure measurement error and temporal confounding. The MESA Air study advanced our understanding of the impact of air pollutants on cardiovascular disease and provided a research platform for advances in environmental epidemiology.

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Figures

Figure 1
Figure 1
Annual Average Predicted PM2.5 Concentrations (μg/m3) in Los Angeles for the years 2000, 2004, 2008, and 2012.
Figure 2
Figure 2
Year 2000 Annual Average Predicted NO2 Concentrations in Winston-Salem, NC.
Figure 3
Figure 3
Proposed mechanisms of cardiovascular effects from chronic exposure to air pollution. Relevant MESA Air citations are noted. Note: Figure adapted from Cosselman et al. 2015.
See this image and copyright information in PMC

References

    1. Kaufman JD, Adar SD, Allen RW, Barr RG, Budoff MJ, Burke GL, Casillas AM, Cohen MA, Curl CL, Daviglus ML, Diez Roux AV, Jacobs DR, Jr., Kronmal RA, Larson TV, Liu SL, Lumley T, Navas-Acien A, O'Leary DH, Rotter JI, Sampson PD, Sheppard L, Siscovick DS, Stein JH, Szpiro AA, Tracy RP. Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). American Journal of Epidemiology. 2012;176(9):825–837. - PMC - PubMed
    1. USEPA . Air Quality Trends. U.S. Environmental Protection Agency; 2015.
    1. USEPA . In: Our Nation's Air - Status and Trends though 2010. Standards OoAQPa., editor. U.S. Environmental Protection Agency; Research Triangle Park, NC: 2012.
    1. Cohen MA, Adar SD, Allen RW, Avol E, Curl CL, Gould T, Hardie D, Ho A, Kinney P, Larson TV. Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and air pollution (MESA air). Environmental Science & Technology. 2009;43(13):4687–4693. - PMC - PubMed
    1. Vedal S, Kim S, Miller K, Fox J, Bergen S, Gould T. Research Report 178) Health Effects Institute; Boston, MA: 2013. NPACT epidemiologic study of components of fine particulate matter and cardiovascular disease in the MESA and WHI-OS cohorts.

MeSH terms