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. 2016 Oct;117(4):382-386.e1.
doi: 10.1016/j.anai.2016.07.042.

Patterns of allergen sensitization and self-reported allergic disease in parents of food allergic children

Melanie M Makhija  1 , Rachel G Robison  2 , Deanna Caruso  3 , Miao Cai  4 , Xiaobin Wang  5 , Jacqueline A Pongracic  1
Affiliations

Patterns of allergen sensitization and self-reported allergic disease in parents of food allergic children

Melanie M Makhija et al. Ann Allergy Asthma Immunol. 2016 Oct.

Abstract

Background: Sensitization in adults has not been extensively studied.

Objective: To investigate patterns of allergen sensitization in parents of food allergic children and to compare self-report of allergic disease with specific IgE (sIgE) measurements.

Methods: A total of 1,252 mothers and 1,225 fathers of food allergic children answered standardized questionnaires about demographics, home environment, history of atopic diseases, and food allergy. Skin prick testing and sIgE serum tests were performed to 9 foods and 5 aeroallergens.

Results: A total of 66.1% of parents were sensitized to either a food or aeroallergen. Mean sIgE levels were low for all foods tested. A total of 14.5% of mothers and 12.7% of fathers reported current food allergy. Only 28.4% had sensitization to their reported allergen. Fathers had significantly higher rates of sensitization to both foods and aeroallergens (P < .01) than mothers. Logistic regression evaluating predictors of self-reported food allergy revealed statistically significant positive associations in fathers with self-reported asthma, environmental allergy, and eczema. For mothers, significant positive associations were found with environmental allergy and having more than 1 food allergic child.

Conclusion: This cohort of parents of food allergic children found higher rates of sensitization to foods and aeroallergens compared with the general population. However, food sIgE levels were low and correlated poorly with self-reported food allergy. Sex differences in sensitization to foods and aeroallergens were seen.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1. Distribution of Mean Food sIgE Concentrations in Father and Mothers
Figure 2
Figure 2. Prevalence of sensitization among parents with or without self-reported allergy to a food
See this image and copyright information in PMC

References

    1. Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. The Journal of allergy and clinical immunology. 2010;125:1322–6. - PubMed
    1. Prescott S, Allen KJ. Food allergy: riding the second wave of the allergy epidemic. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2011;22:155–60. - PubMed
    1. Chin S, Vickery BP. Pathogenesis of food allergy in the pediatric patient. Current allergy and asthma reports. 2012;12:621–9. - PMC - PubMed
    1. Hourihane JO, Dean TP, Warner JO. Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ (Clinical research ed) 1996;313:518–21. - PMC - PubMed
    1. Sicherer SH, Furlong TJ, Maes HH, Desnick RJ, Sampson HA, Gelb BD. Genetics of peanut allergy: a twin study. The Journal of allergy and clinical immunology. 2000;106:53–6. - PubMed

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