Precision Medicine: What Challenges Are We Facing?

Yu Xue¹, Eric-Wubbo Lameijer², Kai Ye², Kunlin Zhang³, Suhua Chang³, Xiaoyue Wang⁴, Jianmin Wu⁵, Ge Gao⁶, Fangqing Zhao⁷, Jian Li⁸, Chunsheng Han⁹, Shuhua Xu¹⁰, Jingfa Xiao¹¹, Xuerui Yang¹², Xiaomin Ying¹³, Xuegong Zhang¹⁴, Wei-Hua Chen¹⁵, Yun Liu¹⁶, Zhang Zhang¹⁷, Kun Huang¹⁸, Jun Yu¹⁹

Affiliations

¹ MOE Key Laboratory of Molecular Biophysics, College of Life Science and Technology and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan 430074, China.
² School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
³ CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
⁴ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China.
⁵ MOE/Beijing Key Laboratory of Carcinogenesis and Translational Research, Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing 100142, China.
⁶ Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
⁷ Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
⁸ MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China.
⁹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
¹⁰ Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
¹¹ CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing 100101, China.
¹² MOE Key Laboratory of Bioinformatics, School of Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
¹³ Computational Omics Laboratory, Center of Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
¹⁴ Bioinformatics Division, TNLIST and MOE Key Laboratory for Bioinformatics, Department of Automation, Tsinghua University, Beijing 100084, China.
¹⁵ Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
¹⁶ MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
¹⁷ BIG Data Center and CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
¹⁸ Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43017, USA.
¹⁹ CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: junyu@big.ac.cn.

PMID: 27744061
PMCID: PMC5093857
DOI: 10.1016/j.gpb.2016.10.001

Precision Medicine: What Challenges Are We Facing?

Yu Xue et al. Genomics Proteomics Bioinformatics. 2016 Oct.

. 2016 Oct;14(5):253-261.

doi: 10.1016/j.gpb.2016.10.001. Epub 2016 Oct 13.

Authors

Affiliations

¹ MOE Key Laboratory of Molecular Biophysics, College of Life Science and Technology and the Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan 430074, China.
² School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
³ CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
⁴ State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China.
⁵ MOE/Beijing Key Laboratory of Carcinogenesis and Translational Research, Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing 100142, China.
⁶ Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
⁷ Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
⁸ MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China.
⁹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
¹⁰ Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
¹¹ CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing 100101, China.
¹² MOE Key Laboratory of Bioinformatics, School of Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
¹³ Computational Omics Laboratory, Center of Computational Biology, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
¹⁴ Bioinformatics Division, TNLIST and MOE Key Laboratory for Bioinformatics, Department of Automation, Tsinghua University, Beijing 100084, China.
¹⁵ Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
¹⁶ MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
¹⁷ BIG Data Center and CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
¹⁸ Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43017, USA.
¹⁹ CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: junyu@big.ac.cn.

PMID: 27744061
PMCID: PMC5093857
DOI: 10.1016/j.gpb.2016.10.001

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Figures

**Figure 1**
The knowledge framework of Precision Medicine Precision Medicine is built upon big biological and clinical data of large cohorts of patients and healthy controls. Bioinformatics covers all the processes from data analysis to medical decision.

See this image and copyright information in PMC

References

1. National Research Council (US) Committee on A Framework for Developing a New Taxonomy of Disease. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases. Washington DC: National Academies Press, USA; 2011. - PubMed
1. Collins F.S., Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793–795. - PMC - PubMed
1. Chatterjee N., Shi J., García-Closas M. Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat Rev Genet. 2016;17:392–406. - PMC - PubMed
1. Qi J., Zhao F. InGAP-sv: a novel scheme to identify and visualize structural variation from paired end mapping data. Nucleic Acids Res. 2011;39:W567–W575. - PMC - PubMed
1. Zhao H., Zhao F. BreakSeek: a breakpoint-based algorithm for full spectral range INDEL detection. Nucleic Acids Res. 2015;43:6701–6713. - PMC - PubMed

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Precision Medicine: What Challenges Are We Facing?

Affiliations

Precision Medicine: What Challenges Are We Facing?

Authors

Affiliations

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References

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