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. 2016 Dec;86(4):439-441.
doi: 10.1016/j.diagmicrobio.2016.09.002. Epub 2016 Sep 8.

Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae

Kenneth P Smith  1 , James E Kirby  2
Affiliations

Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae

Kenneth P Smith et al. Diagn Microbiol Infect Dis. 2016 Dec.

Abstract

We evaluated activity of apramycin, a non-ototoxic/non-nephrotoxic aminocyclitol against 141 clinical Enterobacteriaceae isolates, 51% of which were non-susceptible to carbapenems (CRE). Among CRE, 70.8% were apramycin susceptible, which compared favorably to aminoglycosides in current clinical use. Our data suggest that apramycin deserves further investigation as a repurposed, anti-CRE therapeutic.

Keywords: Activity spectrum; Aminoglycoside; Apramycin; Carbapenem-resistant Enterobacteriaceae; Multidrug-resistance; Repurposing.

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