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Case Reports
. 2017 May;38(5):340-343.
doi: 10.1016/j.revmed.2016.07.008. Epub 2016 Oct 13.

[Hydroxychloroquine-induced hearing loss: First case of positive rechallenge and analysis of the French pharmacovigilance database]

[Article in French]
J-N Chatelet  1 , M Auffret  2 , S Combret  3 , E Bondon-Guitton  4 , M Lambert  5 , S Gautier  1
Affiliations
Case Reports

[Hydroxychloroquine-induced hearing loss: First case of positive rechallenge and analysis of the French pharmacovigilance database]

[Article in French]
J-N Chatelet et al. Rev Med Interne. 2017 May.

Abstract

Introduction: Several cases of hearing loss induced by hydroxychloroquine have been reported in the literature but the role of hydroxychloroquine still remains debated.

Case report: We report the first case, to our knowledge, of hearing loss induced by hydroxychloroquine with a positive re challenge in a woman treated for systemic lupus. An analysis of the French pharmacovigilance database allowed to identify 23 additional cases of hearing loss in patients treated with hydroxychloroquine and, among them, 8 had systemic lupus.

Conclusion: Despite an excellent tolerance and high efficacy-side effect ratio, this case report adds some evidence for an otoxicity of hydroxychloroquine.

Keywords: Adverse drug reaction; Effet indésirable; Hearing loss; Hydroxychloroquine; Lupus; Perte d’audition; Surdité.

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