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. 2016 Nov 11;34(47):5700-5703.
doi: 10.1016/j.vaccine.2016.09.050. Epub 2016 Oct 13.

Infants with low vaccine antibody responses have altered innate cytokine response

Naveen Surendran  1 , Ted Nicolosi  1 , Michael Pichichero  2
Affiliations

Infants with low vaccine antibody responses have altered innate cytokine response

Naveen Surendran et al. Vaccine. .

Abstract

We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.

Keywords: IFN-α; IL12p70; IRF7; Infant innate immunity; Low vaccine response; RANTES.

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Conflict of interest statement

The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Baseline and R848 induced RANTES (pg/ml) secretion from peripheral blood supernatants of LVR (N=17) and NVR (N=15) infants. Statistical significance was assessed by Mann-Whitney U test and data shows the geometric mean with 95% confidence interval.
Figure 2
Figure 2
R848 induced cytokine secretion (pg/ml) from peripheral blood supernatants of LVR and NVR infants. (A) multi-subtype IFN-α (B) IL-12p70 (C) IL-1β. Statistical significance was assessed by Mann-Whitney U test and data shows the median and interquartile range. IFN-α (LVR, N=14; NVR, N=14), IL-12p70 and IL-1β (LVR, N=17; NVR, N=15).
See this image and copyright information in PMC

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