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. 2016 Sep;6(3):244-245.
doi: 10.1016/j.jceh.2016.02.007. Epub 2016 Mar 4.

Giant-cell Hepatitis-Rare Entity in Adults

Shiran Shetty  1 , Krishnaveni Janarthanan  2 , Venkatakrishnan Leelakrishnan  3 , Vadakkepat Nirmala  3
Affiliations

Giant-cell Hepatitis-Rare Entity in Adults

Shiran Shetty et al. J Clin Exp Hepatol. 2016 Sep.

Abstract

Giant-cell hepatitis (GCH) is characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver. Although it is commonly described in neonates, it rarely occurs in adults. Here we report a case of GCH because of herbal medicine intake.

Keywords: GCH, giant cell hepatitis; MRCP, magnetic resonance cholangiopancreatography; UDCA, ursodeoxycholic acid; giant cell hepatitis (GCH); hepatoxins; herbal medicine.

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Figures

Figure 1
Figure 1
Liver architecture preserved with lobular inflammation (lymphocytes + eosinophils).
Figure 2
Figure 2
Multinucleated giant cells seen along with Kupffer cell hyperplasia, suggestive of giant cell hepatitis.
See this image and copyright information in PMC

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