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. 2016 Oct;28(5):637-639.
doi: 10.5021/ad.2016.28.5.637. Epub 2016 Sep 30.

A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans

Kanami Saito  1 , Hisae Ando  2 , Koro Goto  2 , Tetsuya Kakuma  2 , Yasushi Kawano  3 , Hisashi Narahara  3 , Yutaka Hatano  1 , Sakuhei Fujiwara  1
Affiliations

A Case of Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans Syndrome; Increase in Proliferating Cell Nuclear Antigen and Decrease in Loricrin in Acanthosis Nigricans

Kanami Saito et al. Ann Dermatol. 2016 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1. Hypertrichosis on her face (A: eyebrows, B: chin) and hyperpigmented, velvety patches on her axilla (C), the nape of her neck (D) and the dorsal aspect of her phalangeal joints (E). Histological examination revealed epidermal papillomatosis and acanthosis with orthohyperkeratosis, and no significant inflammatory infiltrate (F). (F) H&E, ×40.
Fig. 2
Fig. 2. Immunohistochemical staining on axilla of the patient revealed the conspicuous increase in proliferating cell nuclear antigen (PCNA)-positive cells, especially in basal layer and the reduced and abnormally expanding expression of loricrin in granular and upper spinous layers. (A) PCNA in a healthy volunteer, (B) PCNA in the patient. (C) loricrin in a healthy volunteer, (D) loricrin in the patient. A~D: ×100.
See this image and copyright information in PMC

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