IL-1 receptor antagonist in sepsis: new findings with old data?
- PMID: 27746981
- PMCID: PMC5059273
- DOI: 10.21037/jtd.2016.08.51
IL-1 receptor antagonist in sepsis: new findings with old data?
Conflict of interest statement
The authors have no conflicts of interest to declare.
Comment on
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Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial.Crit Care Med. 2016 Feb;44(2):275-81. doi: 10.1097/CCM.0000000000001402. Crit Care Med. 2016. PMID: 26584195 Free PMC article. Clinical Trial.
References
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- Opal SM, Fisher CJ, Jr, Dhainaut JF, et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 1997;25:1115-24. 10.1097/00003246-199707000-00010 - DOI - PubMed
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- Fisher CJ, Jr, Dhainaut JF, Opal SM, et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 1994;271:1836-43. 10.1001/jama.1994.03510470040032 - DOI - PubMed
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