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Review
. 2016 Nov 2;14(43):10134-10156.
doi: 10.1039/c6ob01349j.

Biologically active γ-lactams: synthesis and natural sources

J Caruano  1 , G G Muccioli  2 , R Robiette  3
Affiliations
Review

Biologically active γ-lactams: synthesis and natural sources

J Caruano et al. Org Biomol Chem. .

Abstract

The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities.

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