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. 2016 Oct;95(40):e4870.
doi: 10.1097/MD.0000000000004870.

Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China

Wei Li  1 , Zhang Qiong, Shen Xiao-Ting, Liu Yu-Jie, Mao Jian-Hua, Shu Qiang, Shang Shi-Qiang
Affiliations

Molecular epidemiological study of enteroviruses associated with encephalitis in children from Hangzhou, China

Wei Li et al. Medicine (Baltimore). 2016 Oct.

Erratum in

Abstract

Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region.A total of 126 CSF specimens were tested and EV was detected in 26 specimens (20.6%). The molecular typing results showed different types of EV strains including Coxsackievirus B2, Coxsackievirus B3, Echovirus 5, Echovirus 16, Echovirus 18, Echovirus 30, and all EV isolates belonging to the human EV species B.According to the sequence of VP1 and 5'UTR region, E30 may be major cause of children's EVE in Hangzhou, China.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Phylogenetic analysis of the enterovirus isolates based on the VP1 gene (A) or 5′UTR (B) sequences.
See this image and copyright information in PMC

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