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. 2017 Jan;36(1):63-65.
doi: 10.1097/INF.0000000000001354.

T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults

Aviva S Mattingly  1 , Aylin B Unsal, Julia B Purdy, Ahmed M Gharib, Adam Rupert, Joseph A Kovacs, Dorothea McAreavey, Rohan Hazra, Khaled Z Abd-Elmoniem, Colleen Hadigan
Affiliations

T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults

Aviva S Mattingly et al. Pediatr Infect Dis J. 2017 Jan.

Abstract

We evaluated immune activation and coronary artery plaque in young adults with human immunodeficiency virus acquired in early life (n = 31). Coronary plaque was positively associated with lipids, immune activation marker %CD8+CD38+DR+ and E-selectin, a marker of endothelial inflammation. Immune activation and endothelial inflammation may drive coronary plaque formation during the early stages of atherosclerosis in the context of chronic human immunodeficiency virus.

Trial registration: ClinicalTrials.gov NCT00924365 NCT01656564.

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Conflict of interest statement

The authors have no financial conflicts of interest to report in relationship to this research or manuscript.

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