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Review
. 2016 Sep;24(5):554-559.
doi: 10.1016/j.jsps.2015.03.022. Epub 2015 Mar 21.

Methods of synthesis of hydrogels … A review

Muhammad Faheem Akhtar  1 , Muhammad Hanif  1 , Nazar Muhammad Ranjha  1
Affiliations
Review

Methods of synthesis of hydrogels … A review

Muhammad Faheem Akhtar et al. Saudi Pharm J. 2016 Sep.

Abstract

Hydrogels are being investigated recently for the bioactive molecules (in particular pharmaceutical proteins) controlled release, such as matrices, and for the living cells encapsulation. Biodegradable nature of hydrogels has created much interest for drug delivery systems. The original three-dimensional structure disintegrates into nontoxic substances to ascertain an excellent biocompatibility of the gel. Chemical cross-linking is the highly resourceful method for the formation of hydrogels having an excellent mechanical strength. Cross-linkers used in hydrogel preparation should be extracted from the hydrogels before use due to their reported toxicity. Physically cross-linked methods for preparation of hydrogel are the alternate solution of cross-linker toxicity.

Keywords: Chemical cross-linking; Degradation; Drug release; Hydrogel; Physical cross-linking.

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