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Review
. 2016 Sep;4(2-3):61-68.
doi: 10.1159/000447677. Epub 2016 Jul 14.

Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis

Pradeep Kumar  1 , Shubham Misra  1 , Arun Kumar Yadav  1 , Amit Kumar  1 , Mukesh Sriwastva  1 , Kameshwar Prasad  1
Affiliations
Review

Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis

Pradeep Kumar et al. Pulse (Basel). 2016 Sep.

Abstract

Background: Polymorphisms of -174G/C and -572C/G in the Interleukin-6 (IL-6) promoter gene can affect both transcription and secretion of IL-6 and may be involved in the inflammatory mechanisms in early and delayed phases after intracerebral hemorrhage (ICH). The role of these polymorphisms remains unclear for the pathogenesis of ICH.

Methods: PubMed, EMBASE, MEDLINE and Google Scholar searches were conducted from January 1, 1950 to February 29, 2016 and were supplemented with relevant articles identified in the references. The following search terms were used: ('interleukin-6' or 'IL-6') and ('genetic polymorphism' or 'single nucleotide polymorphisms' or 'SNP') and ('intracerebral hemorrhage' or 'ICH') and ('hemorrhagic stroke' or 'HS'). Fixed or random effects models were used to estimate the pooled odds ratios and 95% confidence intervals. Begg's funnel plot was used to assess the potential for publication bias.

Results: In our meta-analysis, three case-control studies involving 446 ICH cases and 2,322 controls were included. No significant association was observed for the IL-6 (-174G/C and -572C/G) gene polymorphisms with the risk of ICH under dominant, recessive and allelic models.

Conclusion: Our meta-analysis suggests that IL-6 gene polymorphisms are not associated with the risk of ICH. However, caution must be taken while considering the results of our meta-analysis due to the presence of small sample size. Our results cannot be extrapolated to represent the effect of entire IL-6 genetic polymorphism on stroke patients worldwide. Therefore, further well-designed studies with large sample size are warranted to validate our findings and provide a profound conclusion.

Keywords: Cytokine; Interleukin-6; Intracerebral hemorrhage; Single nucleotide polymorphisms.

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Figures

Fig. 1
Fig. 1
Flow diagram for the selection of studies and specific reasons for exclusion from the present meta-analysis.
Fig. 2
Fig. 2
Forest plot for the association between IL-6 −174G/C gene polymorphism and risk of ICH. a Dominant model (CC + GC vs. GG). b Recessive model (CC vs. GG + GC). c Allelic model (C allele vs. G allele).
Fig. 3
Fig. 3
Forest plot for the association between IL-6 −572C/G gene polymorphism and risk of ICH. a Dominant model (GG + CG vs. CC). b Recessive model (GG vs. CC + CG). c Allelic model (G allele vs. C allele).
Fig. 4
Fig. 4
Begg's funnel plot for the assessment of publication bias for IL-6 −174G/C (a) and −572C/G (b) gene polymorphisms.
See this image and copyright information in PMC

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