. 2016 Oct 18;15(1):88.

doi: 10.1186/s12937-016-0209-2.

Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

Natalia Sanchez-Aguadero^{1

2}, Rosario Alonso-Dominguez³, Jose I Recio-Rodriguez⁴, Maria C Patino-Alonso⁵, Manuel A Gomez-Marcos⁶, Carlos Martin-Cantera⁷, Yolanda Schmolling-Guinovart⁸, Luis Garcia-Ortiz⁹; EVIDENT II Group

Affiliations

¹ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain. natalia.san.ag@gmail.com.
² Primary care Research Unit, The Alamedilla Health Center, Avda. Comuneros N° 27, 37003, Salamanca, Spain. natalia.san.ag@gmail.com.
³ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁴ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Nursing and Physiotherapy, University of Salamanca, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁵ Department of Statistics, University of Salamanca, Biomedical Research Institute of Salamanca (IBSAL), Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁶ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Medicine, University of Salamanca, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁷ Passeig de Sant Joan Health Center, Catalan Health Service, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Barcelona, Spain.
⁸ Río Tajo Health Center, Castilla-La Mancha Health Service, University of Castilla-La Mancha, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Talavera de la Reina, Spain.
⁹ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Biomedical and Diagnostic Sciences, University of Salamanca, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.

PMID: 27756385
PMCID: PMC5070080
DOI: 10.1186/s12937-016-0209-2

Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

Natalia Sanchez-Aguadero et al. Nutr J. 2016.

. 2016 Oct 18;15(1):88.

doi: 10.1186/s12937-016-0209-2.

Authors

Affiliations

¹ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain. natalia.san.ag@gmail.com.
² Primary care Research Unit, The Alamedilla Health Center, Avda. Comuneros N° 27, 37003, Salamanca, Spain. natalia.san.ag@gmail.com.
³ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁴ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Nursing and Physiotherapy, University of Salamanca, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁵ Department of Statistics, University of Salamanca, Biomedical Research Institute of Salamanca (IBSAL), Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁶ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Medicine, University of Salamanca, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.
⁷ Passeig de Sant Joan Health Center, Catalan Health Service, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Barcelona, Spain.
⁸ Río Tajo Health Center, Castilla-La Mancha Health Service, University of Castilla-La Mancha, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Talavera de la Reina, Spain.
⁹ Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service (SACYL), Biomedical Research Institute of Salamanca (IBSAL), Department of Biomedical and Diagnostic Sciences, University of Salamanca, Spanish Network for Preventive Activities and Health Promotion (redIAPP), Salamanca, Spain.

PMID: 27756385
PMCID: PMC5070080
DOI: 10.1186/s12937-016-0209-2

Abstract

Objective: To analyze the relationship between dietary glycemic index (GI) and retinal microvasculature in adults.

Methods: This was a cross-sectional study of 300 subjects from the EVIDENT II study. Dietary GI was calculated using a validated, semi-quantitative food frequency questionnaire. Retinal photographs were digitized, temporal vessels were measured in an area 0.5-1 disc diameter from the optic disc and arteriolar-venular index (AVI) was estimated with semi-automated software.

Results: AVI showed a significant difference between the tertiles of GI, after adjusting for potential confounders. The lowest AVI values were observed among subjects in the highest tertile of GI, whereas the greatest were found among those in the lowest tertile (estimated marginal mean of 0.738 vs. 0.768, p = 0.014).

Conclusions: In adults, high dietary GI implies lowering AVI values regardless of age, gender and other confounding variables.

Trial registration: Clinical Trials.gov Identifier: NCT02016014 . Registered 9 December 2013.

Keywords: Carbohydrates; Glycemic index; Microcirculation; Retinal vessels.

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Figures

**Fig. 1**
Multivariate analysis. Retinal arteriolar-venular index (AVI), retinal arteriolar caliber and retinal venular caliber by tertiles of glycemic index (GI). Model adjusted for age, gender, total energy intake, body mass index (BMI), systolic blood pressure (SBP), antihypertensive drugs, antidiabetic drugs and lipid-lowering drugs. Tertiles (T) GI: T1 (Lowest through 45.98); T2 (45.98 through 50.52); T3 (50.52 through Highest). AVI differences by tertiles of GI: p = 0.033 between T1 and T3, p = 0.031 between T2 and T3. Post-hoc contrasts were performed by the Bonferroni test

See this image and copyright information in PMC

References

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Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

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Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

Authors

Affiliations

Abstract

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References

Publication types

MeSH terms

Associated data

LinkOut - more resources

Full Text Sources

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Medical