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. 2016 Oct 18;14(1):266.
doi: 10.1186/s12957-016-1014-2.

Intraoperative indocyanine green fluorescence guidance for excision of nonpalpable breast cancer

Jintao Liu  1 , Wenbin Guo  2 , Meng Tong  1
Affiliations

Intraoperative indocyanine green fluorescence guidance for excision of nonpalpable breast cancer

Jintao Liu et al. World J Surg Oncol. .

Abstract

Background: Different techniques have been used for the guidance of nonpalpable breast cancer (NBC), but none of them has yet achieved perfect results. The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescence-guided nonpalpable breast cancer lesion excision (IFNLE), to introduce an alternative technique.

Methods: The data about 56 patients with preoperatively diagnosed NBCs operated with the help of intraoperative IFNLE between November of 2010 and September of 2014 were retrospectively analyzed.

Results: ICG fluorescence localized all lesions at surgery. Re-excision due to positive resection margins was necessary in two patients (3.6 %; 2/56) with ductal carcinoma in situ (DCIS) at the surgical margins. Mastectomy was necessary in one patient (1.8 %; 1/56) due to multifocal invasive carcinoma. The mean volume of the excised tissue was 38.2 ± 16.5 cm3.

Conclusions: IFNLE is a technically applicable and clinically acceptable procedure whenever a breast cancer needs image-guided excision.

Keywords: Indocyanine green fluorescence imaging; Intraoperative excision; Nonpalpable breast cancer.

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Figures

Fig. 1
Fig. 1
Ultrasonographic appearance of a nonpalpable breast lesion: a hypoechoic with irregular margins; b intralesional injection of indocyanine green (ICG) solution with a spinal needle under ultrasound guidance (arrow)
Fig. 2
Fig. 2
a During surgery, a near-infrared-sensitive imaging system was used to observe. b The area of ICG-derived fluorescence
Fig. 3
Fig. 3
a The resection margins were defined under the guidance of fluorescence imaging; b appearance of the specimen after excision
See this image and copyright information in PMC

References

    1. Tabar L, Dean PB, Kaufman CS, Duffy SW, Chen HH. A new era in the diagnosis of breast cancer. Surg Oncol Clin North Am. 2000;9:233–7. - PubMed
    1. Kaufman CS, Jacobson L, Bachman B, Kaufman LBS. Intraoperative ultrasound facilitates surgery for early breast cancer. Ann Surg Oncol. 2002;9:988–93. doi: 10.1007/BF02574517. - DOI - PubMed
    1. Fortunato L, Penteriani R, Farina M, Vitelli CE, Piro FR. Intraoperative ultrasound is an effective and preferable technique to localization of nonpalpable breast tumors. Eur J Surg Oncol. 2008;34:1289–92. doi: 10.1016/j.ejso.2007.11.011. - DOI - PubMed
    1. Inui H, Watatani M, Hashimoto Y, Hojo T, Hirai K, Yamato M, et al. Hematoma-directed and ultrasound-guided breast-conserving surgery for nonpalpable breast cancer after mammotome biopsy. Surg Today. 2008;38:279–82. doi: 10.1007/s00595-007-3595-4. - DOI - PubMed
    1. Aydogan F, Ozben V, Celik V, Uras C, Tahan G, Gazioglu E, et al. Radioguided occult lesion localization for non-palpable breast cancer: a comparison between day-before and same-day protocols. Breast. 2010;19:226–30. doi: 10.1016/j.breast.2010.01.017. - DOI - PubMed

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