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Meta-Analysis
. 2016 Nov 22;36(6):e00414.
doi: 10.1042/BSR20160341. Print 2016 Dec.

The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies

Tao Zhang  1 , Hongqiang Chen  1 , Shiyong Qin  1 , Minghai Wang  1 , Xianming Wang  1 , Xin Zhang  1 , Fei Liu  1 , Shuguang Zhang  2
Affiliations
Meta-Analysis

The association between dietary vitamin A intake and pancreatic cancer risk: a meta-analysis of 11 studies

Tao Zhang et al. Biosci Rep. .

Abstract

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712-0.988) with low heterogeneity detected (I2=17.8%, Pheterogeneity=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690-0.947], as well as in European population [RR=0.821, 95% CI=0.693-0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

Keywords: meta-analysis; pancreatic cancer; vitamin A.

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Figures

Figure 1
Figure 1. The flow diagram of screened, excluded and analyzed publications
Figure 2
Figure 2. The forest plot between highest compared with lowest categories of dietary vitamin A intake and pancreatic cancer risk
Figure 3
Figure 3. The funnel plot of the association between dietary vitamin A intake and pancreatic cancer risk
See this image and copyright information in PMC

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