Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 25;5(4):364-371.
doi: 10.5455/jice.20160923100102. eCollection 2016 Sep-Dec.

Antidiabetic and antioxidant effects of Croton lobatus L. in alloxan-induced diabetic rats

Taiye Remi Fasola  1 , Blessing Ukwenya  1 , Ademola Adetokunbo Oyagbemi  2 , Temidayo Olutayo Omobowale  3 , Temitayo Olabisi Ajibade  2
Affiliations

Antidiabetic and antioxidant effects of Croton lobatus L. in alloxan-induced diabetic rats

Taiye Remi Fasola et al. J Intercult Ethnopharmacol. .

Abstract

Background: Croton lobatus contains a high amount of antioxidant phytochemicals that probably account for its wide use as food and medicine in the traditional communities of West Africa.

Methods: The study evaluated the modulatory role of methanol extract of Croton lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications. Male rats were randomly selected and assigned to one of six groups (A to F) of eight animals each: A (distilled water); B (corn oil); C (Alloxan); D (Alloxan + 100 mg kg-1 Croton lobatus); E: (Alloxan + 200 mg kg-1 C. lobatus); and F (Alloxan + 100 mg kg-1 glibenclamide).

Results: Acute toxicity studies revealed no mortality of rats at the administration of different doses of extract up to the 5,000 mg kg-1 dose. Histology of the pancreas showed focal area of necrosis, and fatty infiltration in diabetic untreated rats, but these lesions were absent in pancreas of rats treated with C. lobatus extract.

Conclusion: Methanol leaf extract of C. lobatus reduced arteriogenic risk factors, improved antioxidant status, restored the observable pathological lesions associated with experimental diabetes in rats, and thus offers a new therapeutic window as herbal therapy for the treatment of diabetes mellitus and associated cardiovascular complications.

Keywords: Blood pressure; diabetes; electrocardiogram; oxidative stress.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1
Figure 1
Effect of Croton lobatus leaf extract on pancreas in alloxan–induced diabetic rats. Histology of the pancreas following induction of diabetes mellitus and treatment with C. lobatus leaf extract in rats. (a and b) normal controls with normal Islet; (c) Untreated diabetic group with congestion of vessels, and focal area of necrosis, and fatty infiltration; (d) Diabetic treated with 100 mg/kg C. lobatus with moderate congestion of vessels, islets appear normal but few and small in size; (e) Diabetic treated with 200 mg/kg with mild congestion of vessels and normal islets, and normal exocrine acini containing zymogen granules; (f) Diabetic treated with gilbenclamide shows congestion of vessels, normal islets, and normal exocrine acini containing zymogen granules. Histologic slides were stained with Hematoxylin and Eosin (×400)
See this image and copyright information in PMC

References

    1. Seidell JC. Obesity, insulin resistance and diabetes: A worldwide epidemics. Br J Nutr. 2000;83(Suppl 1):S5–8. - PubMed
    1. Bastaki A. Diabetes mellitus and its treatment. Int J Diabetes Metab. 2005;13:111–34.
    1. Economic consequences of diabetes mellitus in the U.S. in. American Diabetes Association. Diabetes Care. 1998;21:296–309. - PubMed
    1. Danilova IG, Sarapultsev PA, Medvedeva SU, Gette IF, Bulavintceva TS, Sarapultsev AP. Morphological restructuring of myocardium during the early phase of experimental diabetes mellitus. Anat Rec (Hoboken) 2015;298:396–407. - PubMed
    1. Kala C, Ali SS, Abid M, Rajpoot S, Khan NA. Protection against FCA induced oxidative stress induced DNA damage as a model of arthritis and in vitro anti-arthritic potential of Costus specious rhizome extract. Int J Pharmacog Phytochem Res. 2015;7:383–9.

LinkOut - more resources