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Editorial
. 2016 Jul 29;5(9):e1216292.
doi: 10.1080/2162402X.2016.1216292. eCollection 2016.

Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

Luca Antonioli  1 , Corrado Blandizzi  2 , Fabio Malavasi  3 , Davide Ferrari  4 , György Haskó  5
Affiliations
Editorial

Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

Luca Antonioli et al. Oncoimmunology. .

Abstract

The ecto-5'-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.

Keywords: CD73; autophagy; immunotherapy; monoclonal antibody; tumor microenvironment.

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Figures

Figure 1.
Figure 1.
Scheme showing the role played by CD73 in the tumor microenvironment. CD73-derived adenosine shapes the cancer milieu, leading to the generation of a marked immunosuppressive and pro-angiogenic environment that paves the way to neoplasia development. ATP: adenosine triphosphate; AMP: adenosine monophosphate; DC: dendritic cell; MSDC: myeloid-derived suppressor cells; NK cell: natural killer cell; Treg cell: regulatory T cell. ↑: increases; ↓: decreases.
See this image and copyright information in PMC

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References

    1. Antonioli L, Blandizzi C, Pacher P, Hasko G. Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer 2013; 13:842-57; PMID:24226193; http://dx.doi.org/10.1038/nrc3613 - DOI - PubMed
    1. Tsai MJ, Chang WA, Huang MS, Kuo PL. Tumor microenvironment: a new treatment target for cancer. ISRN Biochem 2014; 2014:351959; PMID:25937967; http://dx.doi.org/10.1155/2014/351959 - DOI - PMC - PubMed
    1. Blay J, White TD, Hoskin DW. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res 1997; 57:2602-5; PMID:9205063 - PubMed
    1. Antonioli L, Yegutkin GG, Pacher P, Blandizzi C, Hasko G. Anti-CD73 in cancer immunotherapy: awakening new opportunities. Trends Cancer 2016; 2:95-109; PMID:27014745; http://dx.doi.org/10.1016/j.trecan.2016.01.003 - DOI - PMC - PubMed
    1. Allard D, Allard B, Gaudreau PO, Chrobak P, Stagg J. CD73-adenosine: a next-generation target in immuno-oncology. Immunotherapy 2016; 8:145-63; PMID:26808918; http://dx.doi.org/10.2217/imt.15.106 - DOI - PubMed

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