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. 2016 Oct;6(5):239-245.
doi: 10.1007/s13659-016-0108-4. Epub 2016 Oct 18.

Lactam Triterpenoids from the Bark of Toona sinensis

Qian-Qian Meng  1   2 , Xing-Rong Peng  1   3 , Shuang-Yang Lu  1   2 , Luo-Sheng Wan  1   3 , Xia Wang  1   2 , Jin-Run Dong  1   2 , Rui Chu  1   2 , Lin Zhou  1   3 , Xiao-Nian Li  1   3 , Ming-Hua Qiu  4   5   6
Affiliations

Lactam Triterpenoids from the Bark of Toona sinensis

Qian-Qian Meng et al. Nat Prod Bioprospect. 2016 Oct.

Abstract

Three new limonoid-type triterpenoids, namely toonasins A-C (1-3) with a rare lactam E ring, along with six known compounds (4-9) were isolated from the barks of Toona sinensis. The structures of new compounds were elucidated by interpretation of spectroscopic data, and the relative configuration of compound 1 was further characterized by X-ray crystallographic analyses. The isolated compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480), and compounds 3 and 5 showed weak cytotoxicities.

Keywords: Cytotoxicity; Lactam triterpenoids; Limonoids; Toona sinensis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Structures of compounds 1–9 isolated from the bark of Toona sinensis
Fig. 2
Fig. 2
Key HMBC (H formula image C), 1H-1H COSY (formula image) and ROESY (formula image) correlations of 1
Fig. 3
Fig. 3
X-ray structure of 1
Fig. 4
Fig. 4
The selected HMBC (H formula image C), and 1H-1H COSY (formula image) correlations of compound 3
See this image and copyright information in PMC

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