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. 2016 Nov;45(8):721-728.
doi: 10.1080/08820139.2016.1222206. Epub 2016 Oct 19.

TREG Cells in Cancer: Beyond Classical Immunological Control

Paula D Bos  1
Affiliations

TREG Cells in Cancer: Beyond Classical Immunological Control

Paula D Bos. Immunol Invest. 2016 Nov.

Abstract

A prerequisite for tumor evolution toward a malignant state is the establishment of cell intrinsic and extrinsic mechanisms of immune suppression (Hanahan and Weinberg, 2000, 2011; Schreiber, Old, and Smyth, 2011). Widespread recruitment of Foxp3+ regulatory T cells (TREG) is a prevailing means to dampen antitumor immunity. Advances in the characterization of TREG cell heterogeneity and physiological function of tissue resident TREG cells unfold new possibilities for nontraditional tumor-promoting functions of intratumoral TREG cells. This review will focus on the nonclassical function of TREG cells and their implicancies for cancer biology and treatment.

Keywords: Cancer; T cell; nonclassical functions; tissue T.

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