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. 2016 Oct 1;47(10):908-913.
doi: 10.3928/23258160-20161004-03.

Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response

Yuji Itoh, Daniel Petkovsek, Peter K Kaiser, Rishi P Singh, Justis P Ehlers

Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response

Yuji Itoh et al. Ophthalmic Surg Lasers Imaging Retina. .

Abstract

Background and objective: To assess the relationship between spectral-domain optical coherence tomography (SD-OCT) features and functional outcomes for diabetic macular edema (DME) undergoing treatment with intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA).

Patients and methods: Institutional review board-approved, retrospective, consecutive case series of eyes receiving intravitreal bevacizumab (1.25 mg) for DME. SD-OCT features were evaluated and correlated with functional response to anti-vascular endothelial growth factor (VEGF) therapy.

Results: One hundred fifty-nine eyes of 159 subjects were included in this study. Mean visual acuity improved from 20/76 to 20/58. The proportion of eyes with 20/40 or greater visual acuity increased with treatment (35% at initial visit, 51% at final visit). SD-OCT factors that were associated with functional outcomes to anti-VEGF therapy include ellipsoid zone integrity and severity of intraretinal fluid.

Conclusion: SD-OCT features appear to provide important markers for functional response to anti-VEGF therapy in DME. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:908-913.].

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Figures

Figure 1
Figure 1
Longitudinal ellipsoid zone dynamics stratified by significant visual gain (3 lines or more, A) or significant visual loss (3 lines or more). A. In eyes gaining 3 lines or more, the number of cases with an intact ellipsoid zone increased over time, whereas the number of eyes with severe disruption decreased. B. In the eyes that lost 3 lines or more, the number of eyes with severe disruption increased and the number of eyes with intact ellipsoid zone decreased.
See this image and copyright information in PMC

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