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Comment
. 2016 Oct 18;45(4):717-718.
doi: 10.1016/j.immuni.2016.10.006.

Amyloid Cascade into Clarity

Tara M Weitz  1 , Terrence Town  2
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Amyloid Cascade into Clarity

Tara M Weitz et al. Immunity. .
Free article

Abstract

In a recent issue of Nature, Sevigny et al. (2016) report findings from a phase 1b clinical trial of aducanumab (a monoclonal antibody targeting misfolded amyloid-β peptides), revitalizing the "amyloid cascade hypothesis" and bringing mononuclear phagocytes center stage in the treatment of Alzheimer's disease.

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