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. 2016 Sep;33(5):547-551.
doi: 10.5152/balkanmedj.2016.15881. Epub 2016 Sep 1.

Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Hakan Korkmaz  1 , Suzan Tabur  2 , Esen Savaş  3 , Mesut Özkaya  2 , Şefika Nur Aksoy  4 , Nurten Aksoy  5 , Ersin Akarsu  2
Affiliations

Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Hakan Korkmaz et al. Balkan Med J. 2016 Sep.

Abstract

Background: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD).

Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AITD.

Study design: Case control study.

Methods: Fifty patients with AITD (25 Hashimoto's thyroiditis (HT) and 25 Graves' disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed.

Results: The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with -SH level in the patients with AITD.

Conclusion: Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH.

Keywords: Autoimmune thyroid disease; S100A8/S100A9; oxidative status.

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Conflict of interest statement

No conflict of interest was declared by the authors.

Figures

FIG. 1.
FIG. 1.
Serum S100A8/S100A9 levels of the groups Data in which non-parametric tests were used. Graves’ disease, GD; Hashimoto’s thyroiditis, HT; healthy control, HC. GD versus HC: p<0.001, HT versus HC: p<0.001
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