Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep;33(5):547-551.
doi: 10.5152/balkanmedj.2016.15881. Epub 2016 Sep 1.

Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Hakan Korkmaz  1 , Suzan Tabur  2 , Esen Savaş  3 , Mesut Özkaya  2 , Şefika Nur Aksoy  4 , Nurten Aksoy  5 , Ersin Akarsu  2
Affiliations

Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases

Hakan Korkmaz et al. Balkan Med J. 2016 Sep.

Abstract

Background: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD).

Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AITD.

Study design: Case control study.

Methods: Fifty patients with AITD (25 Hashimoto's thyroiditis (HT) and 25 Graves' disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed.

Results: The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with -SH level in the patients with AITD.

Conclusion: Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH.

Keywords: Autoimmune thyroid disease; S100A8/S100A9; oxidative status.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest was declared by the authors.

Figures

FIG. 1.
FIG. 1.
Serum S100A8/S100A9 levels of the groups Data in which non-parametric tests were used. Graves’ disease, GD; Hashimoto’s thyroiditis, HT; healthy control, HC. GD versus HC: p<0.001, HT versus HC: p<0.001
See this image and copyright information in PMC

References

    1. Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmun Rev. 2015;14:174–180. http://dx.doi.org/10.1016/j.autrev.2014.10.016. - DOI - PubMed
    1. Zarković M. The role of oxidative stress on the pathogenesis of graves’ disease. J Thyroid Res. 2012;2012:302537. http://dx.doi.org/10.1155/2012/302537. - DOI - PMC - PubMed
    1. Marcocci C, Leo M, Altea MA. Oxidative stress in graves’ disease. Eur Thyroid J. 2012;1:80–7. http://dx.doi.org/10.1159/000337976. - DOI - PMC - PubMed
    1. Rostami R, Aghasi MR, Mohammadi A, Nourooz-Zadeh J. Enhanced oxidative stress in Hashimoto’s thyroiditis: interrelationships to biomarkers of thyroid function. Clin Biochem. 2013;46:308–12. http://dx.doi.org/10.1016/j.clinbiochem.2012.11.021. - DOI - PubMed
    1. Stríz I, Trebichavský I. Calprotectin- a pleiotropic molecule in acute and chronic inflammation. Physiol Res. 2004;53:245–53. - PubMed

LinkOut - more resources