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Review
. 2016 Sep-Dec;6(3):231-236.
doi: 10.1016/j.jobcr.2016.01.006. Epub 2016 Feb 19.

Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions - A review

Bhavana Gupta  1 , Shaleen Chandra  2 , Vineet Raj  3 , Vivek Gupta  4
Affiliations
Review

Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions - A review

Bhavana Gupta et al. J Oral Biol Craniofac Res. 2016 Sep-Dec.

Abstract

Angiogenesis is considered to be an important biological process in disease progression and tumorigenesis. Among the various factors associated with angiogenesis, vascular endothelial growth factor (VEGF) is a leading candidate. VEGF induces the proliferation, differentiation, and migration of vascular endothelial cells, increases capillary permeability, and enhances endothelial cell survival by preventing apoptosis. This article reviews and highlights the role of VEGF in health, and various oral diseases.

Keywords: Angiogenesis; Oral cancer; Oral diseases; Oral squamous cell carcinoma (OSCC); Vascular endothelial growth factor (VEGF).

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Figures

Fig. 1
Fig. 1
Schematic representation of ligands of VEGF family and their receptors. VEGF-1, 2, and 3 regulate formation of blood vessels, whereas VEGF-2 and 3 regulate the formation of lymphatic vessels.
Fig. 2
Fig. 2
The interaction of VEGF with its signaling tyrosine kinase receptors.
See this image and copyright information in PMC

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