When to start a renal replacement therapy in acute kidney injury (AKI) patients: many irons in the fire

Affiliations

¹ Department of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy;; Department of Health Science, University of Florence, Florence, Italy.
² Depatment of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.

Editorial

Stefano Romagnoli et al. Ann Transl Med. 2016 Sep.

. 2016 Sep;4(18):355.

doi: 10.21037/atm.2016.08.55.

¹ Department of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy;; Department of Health Science, University of Florence, Florence, Italy.
² Depatment of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.

No abstract available

Conflict of interest statement

The authors have no conflicts of interest to declare.

Timing of renal replacement therapy in critically ill patients with acute kidney injury.
Meersch M, Schmidt C, Schmidt J, Zarbock A. Meersch M, et al. Ann Transl Med. 2016 Sep;4(18):360. doi: 10.21037/atm.2016.09.05. Ann Transl Med. 2016. PMID: 27775733 Free PMC article. No abstract available.

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit.
Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Pons B, Boulet E, Boyer A, Chevrel G, Lerolle N, Carpentier D, de Prost N, Lautrette A, Bretagnol A, Mayaux J, Nseir S, Megarbane B, Thirion M, Forel JM, Maizel J, Yonis H, Markowicz P, Thiery G, Tubach F, Ricard JD, Dreyfuss D; AKIKI Study Group. Gaudry S, et al. N Engl J Med. 2016 Jul 14;375(2):122-33. doi: 10.1056/NEJMoa1603017. Epub 2016 May 15. N Engl J Med. 2016. PMID: 27181456 Clinical Trial.
Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial.
Zarbock A, Kellum JA, Schmidt C, Van Aken H, Wempe C, Pavenstädt H, Boanta A, Gerß J, Meersch M. Zarbock A, et al. JAMA. 2016 May 24-31;315(20):2190-9. doi: 10.1001/jama.2016.5828. JAMA. 2016. PMID: 27209269 Clinical Trial.

1. KDIGO AKI Work Group KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:1-138.
1. Kellum JA, Mehta RL, Levin A, et al. Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process. Clin J Am Soc Nephrol 2008;3:887-94. 10.2215/CJN.04891107 - DOI - PubMed
1. Palevsky PM, Baldwin I, Davenport A, et al. Renal replacement therapy and the kidney: minimizing the impact of renal replacement therapy on recovery of acute renal failure. Curr Opin Crit Care 2005;11:548-54. 10.1097/01.ccx.0000179936.21895.a3 - DOI - PubMed
1. Zarbock A, Kellum JA, Schmidt C, et al. Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial. JAMA 2016;315:2190-9. 10.1001/jama.2016.5828 - DOI - PubMed
1. Gaudry S, Hajage D, Schortgen F, et al. Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit. N Engl J Med 2016;375:122-33. 10.1056/NEJMoa1603017 - DOI - PubMed