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Review
. 2016 Sep;17(3):247-258.
doi: 10.1007/s11154-016-9390-z.

Skin steroidogenesis in health and disease

Georgios Nikolakis  1 , Constantine A Stratakis  2 , Theodora Kanaki  3 , Andrej Slominski  4 , Christos C Zouboulis  3
Affiliations
Review

Skin steroidogenesis in health and disease

Georgios Nikolakis et al. Rev Endocr Metab Disord. 2016 Sep.

Abstract

The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.

Keywords: 5a-reductase; Acne; Androgen receptor; Androgens; Aromatase; DHEA; Dermatoendocrinology; Estrogens; Glucocorticoids; Rosacea; Steroidogenesis; Steroids; Testosterone.

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