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Comparative Study
. 1978 Jul;36(7):530-3.

Microscarring in skeletal muscle after repeated exposures to lidocaine with epinephrine

P W Benoit
  • PMID: 277638
Comparative Study

Microscarring in skeletal muscle after repeated exposures to lidocaine with epinephrine

P W Benoit. J Oral Surg. 1978 Jul.

Abstract

To assess the effect of repeated exposures to clinically used local anesthetic, rat thighs were given up to five supramuscular injections of 2% lidocaine with epinephrine, 1:50,000. Substantial damage to muscles followed by rapid regeneration occurred; however, in some areas evidence of retarded regeneration of muscles and microscarring was observed.

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