Unmasking PTEN's nuclear functions
- PMID: 27764547
- PMCID: PMC5224454
- DOI: 10.1080/15384101.2016.1241606
Unmasking PTEN's nuclear functions
Keywords: Chromosomal instability; Mitosis; PLK1; PTEN; Phosphatase activity.
Comment on
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PTEN regulates PLK1 and controls chromosomal stability during cell division.Cell Cycle. 2016 Sep 16;15(18):2476-85. doi: 10.1080/15384101.2016.1203493. Epub 2016 Jul 11. Cell Cycle. 2016. PMID: 27398835 Free PMC article.
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- Bassi C, et al.. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science 2014; 341:395-9; http://dx.doi.org/ 10.1126/science.1236188 - DOI - PMC - PubMed
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- Shen WH, et al.. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007; 128:157-70; PMID:17218262; http://dx.doi.org/ 10.1016/j.cell.2006.11.042 - DOI - PubMed
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- Choi BH, Pagano M, Huang C, Dai W. Cdh1, a Substrate-recruiting Component of Anaphase-promoting Complex/Cyclosome (APC/C) Ubiquitin E3 Ligase, Specifically Interacts with Phosphatase and Tensin Homolog (PTEN) and Promotes Its Removal from Chromatin. J Biol Chem 2014; 289:17951-9; PMID:24811168; http://dx.doi.org/ 10.1074/jbc.M114.559005 - DOI - PMC - PubMed
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- Zhang Z, Hou S-Q, He J, Gu T, Yin Y, Shen WH. PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle 2016; 15(18):2476-85; PMID:27398835; http://dx.doi.org/27492783 10.1080/15384101.2016.1203493 - DOI - PMC - PubMed
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