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Review
. 2016 Oct 4;14(Suppl 1):18.
doi: 10.1186/s12959-016-0113-1. eCollection 2016.

Anti-thrombotic agents derived from snake venom proteins

Tur-Fu Huang  1 , Chun-Chieh Hsu  1 , Yu-Ju Kuo  1
Affiliations
Review

Anti-thrombotic agents derived from snake venom proteins

Tur-Fu Huang et al. Thromb J. .

Abstract

Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and integrins αIIbβ3, αvβ3, α5β1 expressed on platelets, endothelial cells, phagocytes, tumor cells, thus affecting cell-matrices and cell-cell interactions. Here, we focus on disintegrins, a class of low molecular mass Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptide derived from various viper snake venoms. This review describes the potential applications of disintegrins in field of integrin-related diseases, especially arterial thrombosis, angiogenesis, tumor progression and septic inflammation. In addition, a novel RGD-containing disintegrin TMV-7 is being developed as a safer antithrombotic agent with minimal side effects, such as thrombocytopenia and bleeding.

Keywords: Angiogenesis; Antithrombotic agent; Arterial thrombosis; Disintegrins; Septic inflammation; Snake venom proteins.

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