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. 2016 Oct 4;14(Suppl 1):40.
doi: 10.1186/s12959-016-0095-z. eCollection 2016.

Thrombopoietin and its receptor in normal and neoplastic hematopoiesis

Kenneth Kaushansky  1
Affiliations

Thrombopoietin and its receptor in normal and neoplastic hematopoiesis

Kenneth Kaushansky. Thromb J. .

Abstract

Thrombopoietin was posited to exist in 1958 and cloned in 1994, and in the ensuing two decades we have learned a great deal about the physiology and pathology of the primary regulator of thrombopoiesis. This paper will review the role of the hormone and its receptor, the product of the c-Mpl proto-oncogene, in health and disease, including many unexpected effects in both normal and neoplastic hematopoiesis. Amongst these unexpected properties are a non-redundant effect on hematopoietic stem cells, a critical role in all three of the acquired, chronic myeloproliferative neoplasms, as well as both gain-of-function and loss-of-function mutations in congenital and acquired states of thrombocytopenia and thrombocythemia.

Keywords: Hematopoiesis; Thrombopoietin.

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