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Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

Antonio Augusto Moura da Silva et al. Emerg Infect Dis. 2016 Nov.

Abstract

We report the early growth and neurologic findings of 48 infants in Brazil diagnosed with probable congenital Zika virus syndrome and followed to age 1-8 months. Most of these infants had microcephaly (86.7%) and craniofacial disproportion (95.8%). The clinical pattern included poor head growth with increasingly negative z-scores, pyramidal/extrapyramidal symptoms, and epilepsy.

Keywords: Zika virus infection; birthweight; congenital abnormalities; epilepsy; growth; infants; microcephaly; neurologic; outcomes; viruses.

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Figures

Figure 1
Figure 1
Characteristic phenotype of fetal brain disruption sequence in infants with probable congenital Zika virus syndrome, Sao Luís, Brazil, 2015–2016. A) Craniofacial disproportion and biparietal depression. B) Prominent occiput.
Figure 2
Figure 2
Weight (A), length (B), and head circumference (C) z-scores from birth to 1–8 months of age among infants with probable congenital Zika virus syndrome, Sao Luís, Brazil, 2015–2016. The thick black line depicts the mean z-score at birth and the mean rate of change in the z-score over time, estimated in a random-intercept multilevel linear regression model.
See this image and copyright information in PMC

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