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Comment
. 2016 Oct 20;167(3):598-600.
doi: 10.1016/j.cell.2016.10.007.

Unwinding Limb Development

Diego Villar  1 , Duncan T Odom  2
Affiliations
Free article
Comment

Unwinding Limb Development

Diego Villar et al. Cell. .
Free article

Abstract

The molecular mechanisms underpinning vertebrate body plan evolution are beginning to be unravelled. In this issue of Cell, Kvon et al. spectacularly demonstrate how transplanting snake-specific genetic changes found uniquely in serpent enhancers leads to limb loss in mice.

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  • Progressive Loss of Function in a Limb Enhancer during Snake Evolution.
    Kvon EZ, Kamneva OK, Melo US, Barozzi I, Osterwalder M, Mannion BJ, Tissières V, Pickle CS, Plajzer-Frick I, Lee EA, Kato M, Garvin TH, Akiyama JA, Afzal V, Lopez-Rios J, Rubin EM, Dickel DE, Pennacchio LA, Visel A. Kvon EZ, et al. Cell. 2016 Oct 20;167(3):633-642.e11. doi: 10.1016/j.cell.2016.09.028. Cell. 2016. PMID: 27768887 Free PMC article.

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