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Review
. 2016 Oct 20;167(3):606-609.
doi: 10.1016/j.cell.2016.09.030.

p62 in Cancer: Signaling Adaptor Beyond Autophagy

Jorge Moscat  1 , Michael Karin  2 , Maria T Diaz-Meco  3
Affiliations
Review

p62 in Cancer: Signaling Adaptor Beyond Autophagy

Jorge Moscat et al. Cell. .

Abstract

Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.

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Figures

Figure 1
Figure 1. p62 signaling functions in the tumor epithelium and stroma
(A) Structural domain organization of p62, binding partners and signaling functions. p62 has a PB1 domain, a ZZ-type zinc finger domain, a TRAF6-binding (TB) domain, an LC3-interacting region (LIR), a Keap1-interacting region, and a ubiquitin-associated domain (UBA). (B) Central role of p62 accumulation in the tumor epithelium during cancer initiation through detoxification and mTORC1 activation. (C) Role of p62 downregulation in the tumor stroma through the inhibition of mTORC1 in metabolic reprogramming and inflammation
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