Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

Alexander Mischnik¹, Philipp Baumert², Axel Hamprecht³, Anna Rohde⁴, Silke Peter⁵, Susanne Feihl⁶, Johannes Knobloch⁷, Hanna Gölz⁸, Axel Kola⁴, Birgit Obermann⁹, Christiane Querbach⁶, Matthias Willmann⁵, Friedemann Gebhardt⁶, Evelina Tacconelli¹⁰, Petra Gastmeier⁴, Harald Seifert³, Winfried V Kern²; DZIF-ATHOS Study Group

Affiliations

¹ German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: alexander.mischnik@uniklinik-freiburg.de.
² German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
³ German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, 50937, Germany.
⁴ German Center for Infection Research (DZIF), Germany; Institute for Hygiene and Environmental Medicine, National Reference Centre for the Surveillance of Nosocomial Infections, Charité-University Hospital, Berlin, 12203, Germany.
⁵ German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, 72076, Germany.
⁶ German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, 81675, Germany.
⁷ German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, 23538, Germany; Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
⁸ German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Freiburg, 79106, Germany.
⁹ German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, 23538, Germany.
¹⁰ German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Internal Medicine 1, University Hospital Tübingen, Tübingen, 72076, Germany.

PMID: 27769572
DOI: 10.1016/j.diagmicrobio.2016.09.012

Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

Alexander Mischnik et al. Diagn Microbiol Infect Dis. 2017 Jan.

. 2017 Jan;87(1):71-73.

doi: 10.1016/j.diagmicrobio.2016.09.012. Epub 2016 Sep 23.

Authors

Affiliations

¹ German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: alexander.mischnik@uniklinik-freiburg.de.
² German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
³ German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, 50937, Germany.
⁴ German Center for Infection Research (DZIF), Germany; Institute for Hygiene and Environmental Medicine, National Reference Centre for the Surveillance of Nosocomial Infections, Charité-University Hospital, Berlin, 12203, Germany.
⁵ German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Tübingen, Tübingen, 72076, Germany.
⁶ German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, 81675, Germany.
⁷ German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, 23538, Germany; Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
⁸ German Center for Infection Research (DZIF), Germany; Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Freiburg, 79106, Germany.
⁹ German Center for Infection Research (DZIF), Germany; Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, 23538, Germany.
¹⁰ German Center for Infection Research (DZIF), Germany; Division of Infectious Diseases, Department of Internal Medicine 1, University Hospital Tübingen, Tübingen, 72076, Germany.

PMID: 27769572
DOI: 10.1016/j.diagmicrobio.2016.09.012

Abstract

As part of the multicenter Antibiotic Therapy Optimisation Study-the largest study on the prevalence of third-generation cephalosporin-resistant Enterobacteriaceae carriage upon hospital admission-minimum inhibitory concentration values were generated for ampicillin/sulbactam, amoxicillin/clavulanic acid, piperacillin/tazobactam, mecillinam, mecillinam/clavulanic acid, and temocillin against third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species.

Keywords: AmpC; Extended-spectrum β-lactamase; β-Lactamase inhibitor.

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Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

Affiliations

Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

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Abstract

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LinkOut - more resources

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Medical

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