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Review
. 2017 Jun;18(2):83-90.
doi: 10.1007/s10195-016-0434-7. Epub 2016 Oct 21.

Current concepts for the diagnosis and management of eosinophilic granuloma of bone

Andrea Angelini  1 , Andreas F Mavrogenis  2 , Eugenio Rimondi  3 , Giuseppe Rossi  3 , Pietro Ruggieri  4
Affiliations
Review

Current concepts for the diagnosis and management of eosinophilic granuloma of bone

Andrea Angelini et al. J Orthop Traumatol. 2017 Jun.

Abstract

This review summarizes current concepts in the diagnosis and management of the patients with eosinophilic granuloma. Given the benign biology, the clinical course, and the pediatric group of patients that this condition more commonly affects, a treatment approach that carries a lower risk of complications while ensuring a successful cure is desirable. Variable treatment options have been reported with satisfactory results and a recurrence rate of less than 20 %. In this setting, symptomatic lesions that are accessible in the spine or the extremities may be treated with intralesional methylprednisolone injection after tissue biopsy for histological diagnosis.

Keywords: Bone tumors; Eosinophilic granuloma; Extremities; Methylprednisolone injection; Spine.

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Conflict of interest statement

The authors declare that they have no conflict of interest. The authors did not receive any outside funding or grants in support of their research for or preparation of this work. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or non-profit organization with which the authors, or a member of their immediate families, are affiliated or associated.

Figures

Fig. 1
Fig. 1
a Sagittal T2-weighted MRI with fat suppression of the cervical spine of a 43-year-old woman with a painful osteolytic lesion of the C7 vertebral body. b CT-guided frozen section biopsy showed eosinophilic granuloma; intralesional methylprednisolone injection was performed. c Sagittal T2-weighted MRI with fat suppression. d Axial CT scan show complete reconstitution of the lesion 4 years after diagnosis and treatment
Fig. 2
Fig. 2
a Coronal CT scan of the cervical spine of a 5-year-old boy with a painful osteolytic lesion of the C7 vertebral body. b CT-guided frozen section biopsy showed eosinophilic granuloma; intralesional methylprednisolone injection was performed. c, d Sagittal (c)and axial (d) CT scans showing complete reconstitution of the lesion 5 years after diagnosis and treatment
Fig. 3
Fig. 3
a Lateral radiograph of the lumbar spine of a 6-year-old girl with a painful osteolytic lesion of the L2 vertebral body with vertebral plana deformity. CT-guided frozen section biopsy showed eosinophilic granuloma; intralesional methylprednisolone injection was performed. b Lateral radiograph of the lumbar spine shows complete reconstitution of the lesion 7 years after diagnosis and treatment
Fig. 4
Fig. 4
a Anteroposterior radiograph of the pelvis of a 6-year-old boy with a painful osteolytic lesion at the left ischial ramus. CT-guided frozen section biopsy showed eosinophilic granuloma; intralesional methylprednisolone injection was performed. b Anteroposterior radiograph of the pelvis shows complete reconstitution of the lesion 1 year after diagnosis and treatment
See this image and copyright information in PMC

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