In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity
- PMID: 27772545
- DOI: 10.1016/j.jid.2016.08.008
In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity
Abstract
IL-17-driven pathways are active in the skin of patients with psoriasis. Kim et al. examined lesions from mild and moderate to severe psoriasis and found that differences in cutaneous disease severity may be the outcome of lapses in immunoregulatory mechanisms; because as much, if not more, T helper type 17-induced inflammation was seen in mild psoriasis, these patients may also benefit from anti-IL-17-targeted biologics.
Copyright © 2016 The Author. Published by Elsevier Inc. All rights reserved.
Comment on
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The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory Genes.J Invest Dermatol. 2016 Nov;136(11):2173-2182. doi: 10.1016/j.jid.2016.04.032. Epub 2016 May 13. J Invest Dermatol. 2016. PMID: 27185339
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