Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Sep;83(2):159-64.
doi: 10.1007/BF00286710.

Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization

S Pol  1 , B Bousquet-Lemercier, M Pavé-Preux, F Bulle, E Passage, J Hanoune, M G Mattei, R Barouki
Affiliations

Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization

S Pol et al. Hum Genet. 1989 Sep.

Abstract

The localization of the human genes for cytosolic and mitochondrial aspartate aminotransferase (AspAT) has been determined by chromosomal in situ hybridization with specific human cDNA probes previously characterized in our laboratory. The cytosolic AspAT gene is localized on chromosome 10 at the interface of bands q241-q251. Mitochondrial AspAT is characterized by a multigene family located on chromosomes 12 (p131-p132), 16 (q21), and 1 (p32-p33 and q25-q31). Genomic DNA from ten blood donors was digested by ten restriction enzymes, and Southern blots were hybridized with the two specific probes. Restriction fragment length polymorphism was revealed in only one case for cytosolic AspAT, with PvuII, while no polymorphism for mitochondrial AspAT was found.

PubMed Disclaimer

References

    1. J Biol Chem. 1988 Nov 25;263(33):17459-66 - PubMed
    1. Cytogenet Cell Genet. 1978;22(1-6):190-4 - PubMed
    1. J Biol Chem. 1982 Mar 25;257(6):3339-45 - PubMed
    1. J Mol Biol. 1987 Nov 5;198(1):21-31 - PubMed
    1. Ann Hum Genet. 1982 May;46(Pt 2):145-52 - PubMed

Publication types

LinkOut - more resources