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Review
. 2016 Sep;36(5):397-404.
doi: 10.1016/j.semnephrol.2016.05.016.

Human Papillomavirus in Kidney Transplant Recipients

Peter V Chin-Hong  1
Affiliations
Review

Human Papillomavirus in Kidney Transplant Recipients

Peter V Chin-Hong. Semin Nephrol. 2016 Sep.

Abstract

Human papillomavirus (HPV) is a common infection in kidney transplant recipients. HPV causes cervical, anal, vulvar, vaginal, penile and head and neck cancers. Kidney transplant recipients have a disproportionate burden of disease given prolonged immunosuppression. Given the long pre-invasive state of precancer lesions such as cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN) most HPV-cancers are preventable with screening and targeted treatment of disease. Pre-transplant vaccination of age-eligible kidney transplant recipients is otherwise ideal.

Keywords: HPV; Pap test; anal cancer; cervical cancer; kidney transplant; vaccine.

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Figures

Figure 1
Figure 1
High-grade anal intraepithelial neoplasia (AIN) in a female kidney transplant recipient with a history of cervical intraepithelial neoplasia (CIN).
Figure 2
Figure 2
Screening for cervical intraepithelial neoplasia (CIN) and cervical cancer in the kidney transplant patient. ASC-H, atypical squamous cells, cannot exclude HSIL; ASC-US, atypical squamous cells of undetermined significance; HR HPV, high-risk HPV test; HSIL, high-grade squamous intraepithelial lesions; LSIL, low-grade squamous intraepithelial lesions.
Figure 3
Figure 3
Screening for AIN and anal cancer in the kidney transplant patient ASC-H, atypical squamous cells, cannot exclude HSIL; ASC-US, atypical squamous cells of undetermined significance; HSIL, high-grade squamous intraepithelial lesions; LSIL, low-grade squamous intraepithelial lesions.
See this image and copyright information in PMC

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