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Meta-Analysis
. 2016 Oct 24:6:35869.
doi: 10.1038/srep35869.

Adverse Cardiovascular Outcomes associated with Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention with Everolimus Eluting Stents: A Meta-Analysis

Pravesh Kumar Bundhun  1 , Manish Pursun  2 , Abhishek Rishikesh Teeluck  2 , Akash Bhurtu  2 , Mohammad Zafooruddin Sani Soogund  2 , Wei-Qiang Huang  1
Affiliations
Meta-Analysis

Adverse Cardiovascular Outcomes associated with Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention with Everolimus Eluting Stents: A Meta-Analysis

Pravesh Kumar Bundhun et al. Sci Rep. .

Abstract

This study aimed to compare the mid-term adverse cardiovascular outcomes associated with Coronary Artery Bypass Surgery (CABG) and Percutaneous Coronary Intervention (PCI) with Everolimus Eluting Stents (EES). Electronic databases were searched for studies comparing the mid-term (>1 year) adverse cardiovascular outcomes between CABG and PCI with EES. Odd Ratios (OR) with 95% Confidence Intervals (CIs) were calculated and the pooled analyses were performed with RevMan 5.3 software. A total number of 5207 patients were involved in this analysis. No significant difference was observed in mortality between CABG and EES with OR: 0.90, 95% CI: 0.73-1.10; P = 0.30. Moreover, CABG was associated with a high stroke rate, with OR: 0.73, 95% CI: 0.45-1.17; P = 0.19, without any statistical significant. CABG was associated with significantly lower Major Adverse Cardiac Events and Myocardial Infarction with OR: 1.46, 95% CI: 1.05-2.04; P = 0.03 and OR: 1.46, 95% CI: 1.01-2.12; P = 0.05 respectively whereas PCI was associated with a significantly higher repeated revascularization with OR: 2.21; 95% CI: 1.76-2.77; P = 0.00001. In conclusion, significant differences were noted in several subgroups analyzing the mid-term cardiovascular outcomes between CABG and EES.

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Figures

Figure 1
Figure 1. Flow diagram representing the study selection.
Figure 2
Figure 2. Adverse Cardiovascular Outcomes reported between CABG and PCI with EES.
Figure 3
Figure 3. Mortality reported between CABG and PCI with EES in patients with left main coronary diseases.
Figure 4
Figure 4. Adverse Cardiovascular Outcomes reported between CABG and PCI with EES in patients with multi-vessel coronary diseases.
Figure 5
Figure 5. Funnel plot showing sensitivity analysis.
See this image and copyright information in PMC

References

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