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. 2017 Mar;22(2):127-132.
doi: 10.1080/1354750X.2016.1252949. Epub 2016 Nov 7.

Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis

Bruno da Silveira Colombo  1 , Marcelo Fernando Ronsoni  1 , Pedro Eduardo Soares E Silva  1 , Leonardo Fayad  1 , Letícia Muraro Wildner  2 , Maria Luiza Bazzo  2 , Esther Buzaglo Dantas-Correa  1 , Janaína Luz Narciso-Schiavon  1 , Leonardo Lucca Schiavon  1
Affiliations

Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis

Bruno da Silveira Colombo et al. Biomarkers. 2017 Mar.

Abstract

Context: IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown.

Objectives: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis.

Materials and methods: Cohort study that included 103 patients. IGF-I was measured by enzyme-linked immunosorbent assay (ELISA).

Results: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGF-I. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I ≥13 ng/mL and 63.2% for patients with IGF-I <13 ng/mL (p = .001).

Discussion and conclusion: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.

Keywords: IGF-I; Liver cirrhosis; ascites; portal hypertension.

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