Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys

Peter de Jonge¹, Annelieke M Roest¹, Carmen C W Lim², Silvia E Florescu³, Evelyn J Bromet⁴, Dan J Stein⁵, Meredith Harris⁶, Vladimir Nakov⁷, Jose Miguel Caldas-de-Almeida⁸, Daphna Levinson⁹, Ali O Al-Hamzawi¹⁰, Josep Maria Haro¹¹, Maria Carmen Viana¹², Guilherme Borges¹³, Siobhan O'Neill¹⁴, Giovanni de Girolamo¹⁵, Koen Demyttenaere¹⁶, Oye Gureje¹⁷, Noboru Iwata¹⁸, Sing Lee¹⁹, Chiyi Hu²⁰, Aimee Karam²¹, Jacek Moskalewicz²², Viviane Kovess-Masfety²³, Fernando Navarro-Mateu²⁴, Mark Oakley Browne²⁵, Marina Piazza²⁶, José Posada-Villa²⁷, Yolanda Torres²⁸, Margreet L Ten Have²⁹, Ronald C Kessler³⁰, Kate M Scott²

Affiliations

¹ Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
³ National School of Public Health, Management and Professional Development, Bucharest, Romania.
⁴ Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, New York, USA.
⁵ Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Republic of South Africa.
⁶ School of Public Health, University of Queensland, Herston, QLD, Australia.
⁷ Department of Mental Health, National Center of Public Health and Analyses, Sofia, Bulgaria.
⁸ Chronic Diseases research Center (CEDOC) and Department of Mental Health, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisboa, Portugal.
⁹ Mental Health Services, Ministry of Health Israel, Israel.
¹⁰ College of Medicine, Al-Qadisiya University, Al Diwaniya City, Iraq.
¹¹ CIBERSAM, Parc Sanitari Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain.
¹² Department of Social Medicine, Federal University of Espirito Santo, Brazil.
¹³ Instituo Nacional der Psiquiatria, Calzada Mexico Xochimilco, Mexico.
¹⁴ School of Psychology, University of Ulster, Londonderry, UK.
¹⁵ IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
¹⁶ Department of Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.
¹⁷ Department of Psychiatry, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.
¹⁸ Department of Psychology, Hiroshima International University, Hiroshima, Japan.
¹⁹ Department of Psychiatry, The Chinese University of Hongkong, Hongkong, China.
²⁰ Institute of Mental Health, Peking University, Beijing, China.
²¹ Institute for Development, Research, Advocacy and Applied Care (IDRAAC), Beirut, Lebanon.
²² Institute of Psychiatry and Neurology, Warsaw, Poland.
²³ Ecole des Hautes Estudies en Sante Pulbique, Paris Descartes University, Paris, France.
²⁴ Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca. Centro de Investigación Biomédica en Red. Epidemiología y Salud Pública (CIBERESP)-Murcia. Subdirección General de Salud Mental y Asistencia Psiquiátrica. Servicio Murciano de Salud, El Palmar (Murcia), Spain.
²⁵ Centre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, Australia.
²⁶ National Institute of Health, Peru, Universidad Cayetano Hereidia, St. Martin de Porres, Peru.
²⁷ El Bosque University, Bogota, Colombia.
²⁸ Center for Excellence on Research in Mental Health, CES University, Medellin, Colombia.
²⁹ Trimbos Instituut, Netherlands Institute of Mental Health and Addiction, Utrecht, Netherlands.
³⁰ Department of Health Care Policy, Harvard University Medical School, Boston, MA, USA.

PMID: 27775828
PMCID: PMC5143159
DOI: 10.1002/da.22572

Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys

Peter de Jonge et al. Depress Anxiety. 2016 Dec.

. 2016 Dec;33(12):1155-1177.

doi: 10.1002/da.22572. Epub 2016 Oct 24.

Authors

Affiliations

¹ Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
² Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
³ National School of Public Health, Management and Professional Development, Bucharest, Romania.
⁴ Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, New York, USA.
⁵ Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, Republic of South Africa.
⁶ School of Public Health, University of Queensland, Herston, QLD, Australia.
⁷ Department of Mental Health, National Center of Public Health and Analyses, Sofia, Bulgaria.
⁸ Chronic Diseases research Center (CEDOC) and Department of Mental Health, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisboa, Portugal.
⁹ Mental Health Services, Ministry of Health Israel, Israel.
¹⁰ College of Medicine, Al-Qadisiya University, Al Diwaniya City, Iraq.
¹¹ CIBERSAM, Parc Sanitari Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain.
¹² Department of Social Medicine, Federal University of Espirito Santo, Brazil.
¹³ Instituo Nacional der Psiquiatria, Calzada Mexico Xochimilco, Mexico.
¹⁴ School of Psychology, University of Ulster, Londonderry, UK.
¹⁵ IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy.
¹⁶ Department of Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium.
¹⁷ Department of Psychiatry, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.
¹⁸ Department of Psychology, Hiroshima International University, Hiroshima, Japan.
¹⁹ Department of Psychiatry, The Chinese University of Hongkong, Hongkong, China.
²⁰ Institute of Mental Health, Peking University, Beijing, China.
²¹ Institute for Development, Research, Advocacy and Applied Care (IDRAAC), Beirut, Lebanon.
²² Institute of Psychiatry and Neurology, Warsaw, Poland.
²³ Ecole des Hautes Estudies en Sante Pulbique, Paris Descartes University, Paris, France.
²⁴ Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca. Centro de Investigación Biomédica en Red. Epidemiología y Salud Pública (CIBERESP)-Murcia. Subdirección General de Salud Mental y Asistencia Psiquiátrica. Servicio Murciano de Salud, El Palmar (Murcia), Spain.
²⁵ Centre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, Australia.
²⁶ National Institute of Health, Peru, Universidad Cayetano Hereidia, St. Martin de Porres, Peru.
²⁷ El Bosque University, Bogota, Colombia.
²⁸ Center for Excellence on Research in Mental Health, CES University, Medellin, Colombia.
²⁹ Trimbos Instituut, Netherlands Institute of Mental Health and Addiction, Utrecht, Netherlands.
³⁰ Department of Health Care Policy, Harvard University Medical School, Boston, MA, USA.

PMID: 27775828
PMCID: PMC5143159
DOI: 10.1002/da.22572

Abstract

Context: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population.

Objective: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions.

Design and setting: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0.

Participants: Respondents (n = 142,949) from 25 high, middle, and lower-middle income countries across the world aged 18 years or older.

Main outcome measures: PD and presence of single and recurrent PAs.

Results: Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM-5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8-2.2) and their course (OR 1.3; 95% CI 1.2-2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9-1.3 and OR 0.7; 95% CI 0.6-0.8). Cross-national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20-47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder.

Conclusions: We extended previous epidemiological data to a cross-national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.

Keywords: anxiety/anxiety disorders; assessment/diagnosis; epidemiology; international; panic attacks/agoraphobia.

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References

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Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys

Affiliations

Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys

Authors

Affiliations

Abstract

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous