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Review
. 2016 Sep 28;4(3):234-240.
doi: 10.14218/JCTH.2016.00026. Epub 2016 Sep 25.

HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals

Donald P Rice Jr  1 , John J Faragon  2 , Sarah Banks  3 , Lisa M Chirch  1
Affiliations
Review

HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals

Donald P Rice Jr et al. J Clin Transl Hepatol. .

Abstract

Therapy for human immunodeficiency virus (HIV) and chronic hepatitis C has evolved over the past decade, resulting in better control of infection and clinical outcomes; however, drug-drug interactions remain a significant hazard. Joint recommendations from the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America regarding drug-drug interactions between HIV antiretroviral agents and direct-acting antiviral agents for treatment of hepatitis C virus (HCV) infection are reviewed here. This review is oriented to facilitate appropriate selection of an antiviral therapy regimen for HCV infection based on the choice of antiretroviral therapy being administered and, if necessary, switching antiretroviral regimens.

Keywords: Antiretroviral therapy; Direct-acting antivirals; Drug interactions; HIV; Hepatitis C; Pharmacokinetics.

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Conflict of interest statement

Dr. Faragon has disclosed that he has received honoraria from AbbVie, BMS, Gilead, Merck, and Viiv.

References

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