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Comment
. 2016 Sep 19:3:46.
doi: 10.21037/sci.2016.08.10. eCollection 2016.

Maintenance of hematopoietic stem cell dormancy: yet another role for the macrophage

Karin Gustafsson  1 , Michael Welsh  2
Affiliations
Comment

Maintenance of hematopoietic stem cell dormancy: yet another role for the macrophage

Karin Gustafsson et al. Stem Cell Investig. .
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic illustration of niche signals maintaining LT-HSC quiescence and differentiation. Signals derived from various cell types such as macrophages, endothelial cells, mesenchymal stromal cells, megakaryocytes and osteoblasts. These have all been suggested to participate in the regulation of LT-HSC dormancy and retention. The cues modulating these processes can be exerted by cell-cell contacts (as is the case in the present study on Darc/CD82), through secretion of cytokines/chemokines (2,4,7,9) and extracellular matrix (ECM) depositions. ECM will regulate focal adhesion kinase (FAK), which suppresses LT-HSC proliferation (15,27). On the other hand, in BCR-ABL-induced myeloid leukemia, increased FAK activity promotes leukemic cell proliferation (28).
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