doi: 10.1016/s0021-9673(01)89689-8.
Isolation of drug residues from tissues by solid phase dispersion
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- PMID: 2777960
- DOI: 10.1016/s0021-9673(01)89689-8
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Isolation of drug residues from tissues by solid phase dispersion
J Chromatogr.
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Abstract
A new method based on solid phase dispersion of tissue for the subsequent isolation of drugs is reported. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be used as a column packing material from which one can isolate drugs in a stepwise fashion based on the solubility characteristics of the drugs in this matrix. The applicability of this approach for multidrug residue extraction from a single sample is demonstrated for compounds representing the organophosphate, benzimidazole anthelmintic and beta-lactam antibiotic drug classes.
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