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. 1989 Jul 28:475:353-61.
doi: 10.1016/s0021-9673(01)89689-8.

Isolation of drug residues from tissues by solid phase dispersion

S A Barker  1 , A R Long, C R Short
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Isolation of drug residues from tissues by solid phase dispersion

S A Barker et al. J Chromatogr. .

Abstract

A new method based on solid phase dispersion of tissue for the subsequent isolation of drugs is reported. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be used as a column packing material from which one can isolate drugs in a stepwise fashion based on the solubility characteristics of the drugs in this matrix. The applicability of this approach for multidrug residue extraction from a single sample is demonstrated for compounds representing the organophosphate, benzimidazole anthelmintic and beta-lactam antibiotic drug classes.

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